Agent Orange is an extremely hazardous chemical deployed by the U.S. military during the Vietnam War to eliminate dense forests and crops—hideouts and food supplies for North Vietnamese forces and the Viet Cong. This operation was part of a program codenamed Operation Ranch Hand, spanning from 1961 to 1971. Over that period, more than 20 million gallons of various herbicides, including Agent Orange, were sprayed across Vietnam, Cambodia, and Laos.
Agent Orange contains dioxin, a highly toxic compound. After the war, dioxin was proven to cause numerous severe health issues. These effects include cancer, birth defects, skin diseases, and serious psychological and neurological disorders. Not only did it impact the Vietnamese population, but American veterans returning home and their families also faced the devastating aftermath of this chemical.
The consequences of Agent Orange have left a lasting pain for generations of Vietnamese people and serve as a tragic lesson about the long-term effects of using chemical weapons in warfare. It stands as a stark reminder of the importance of protecting the environment and humanity from hazardous chemicals.
Operation Ranch Hand: The U.S. Chemical War in Vietnam
During the Vietnam War, the U.S. military launched an aggressive chemical warfare program known as Operation Ranch Hand. From 1961 to 1971, the U.S. sprayed various herbicides over more than 4.5 million acres of forest land in Vietnam to destroy the hiding spots and food supplies of North Vietnamese troops and the Viet Cong.
U.S. military aircraft were used to spray chemicals along roads, rivers, canals, rice fields, and farmland. However, this process not only affected enemy forces but also caused severe damage to the crops and water sources of civilians in South Vietnam.
In total, over 20 million gallons of herbicides were used in Vietnam, Laos, and Cambodia during Operation Ranch Hand. Beyond aerial spraying, these chemicals were also distributed from trucks and handheld devices around U.S. military bases.
Notably, some U.S. soldiers at the time quipped, “Only you can prevent a forest,” a satirical twist on the famous U.S. Forest Service anti-wildfire campaign featuring Smokey the Bear. In reality, however, the consequences of this operation were far from simple, devastating the natural environment and the lives of millions, with effects lingering across generations.

What is Agent Orange?
In Operation Ranch Hand, herbicides were named after the colors marked on the 55-gallon (approximately 208-liter) barrels used for transport and storage.
Besides Agent Orange, the U.S. military also used other chemicals like Agent Pink, Agent Green, Agent Purple, Agent White, and Agent Blue. Each was produced by companies such as Monsanto, Dow Chemical, and others, with varying chemical compositions and strengths.
Agent Orange was the most widely used in Vietnam and the most toxic. It existed in various mixtures, sometimes referred to as Agent Orange I, Agent Orange II, Agent Orange III, and “Super Orange.”
Over 13 million gallons (about 49 million liters) of Agent Orange were used in Vietnam, accounting for nearly two-thirds of the total herbicides deployed during the Vietnam War. Its impact not only ravaged the environment but also left severe health consequences for both Vietnamese people and U.S. soldiers.

Dioxin in Agent Orange
Beyond the active ingredients in Agent Orange, designed to defoliate or kill plants, this chemical contained significant amounts of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), commonly known as dioxin, an extremely toxic compound.
Dioxin was not intentionally added to Agent Orange but was a byproduct of the herbicide production process. It was present in varying concentrations in all herbicides used in Vietnam.
Apart from chemical production, dioxin is also generated through activities like burning waste, combusting gasoline, coal, smoking tobacco, and industrial processes like bleaching. Among dioxin variants, TCDD in Agent Orange is considered the most dangerous, causing severe and long-lasting harm to the environment and human health.
Effects of Agent Orange
Due to the presence of TCDD dioxin in Agent Orange and other Vietnam War herbicides, they caused both immediate and prolonged effects.
Dioxin is a highly persistent chemical, lingering in the environment for years, particularly in soil, lake and river sediments, and the food chain. It accumulates in the fatty tissues of fish, birds, and other animals. Humans are primarily exposed to dioxin through food such as meat, poultry, dairy products, eggs, seafood, and fish.
Laboratory animal studies have proven dioxin to be extremely toxic even in small doses and widely recognized as a carcinogen.
Short-term exposure to dioxin can cause skin darkening, liver damage, and a severe acne-like skin condition called chloracne. Additionally, dioxin is linked to type 2 diabetes, immune system disorders, neurological issues, muscle disorders, hormonal imbalances, and cardiovascular diseases.
Particularly, fetuses are highly sensitive to dioxin, increasing the risk of miscarriage, spina bifida, and severe brain and nervous system developmental issues.

Health Issues for Veterans and Legal Battles Over Agent Orange
Questions about Agent Orange emerged in the U.S. as more Vietnam War veterans and their families reported health problems, including rashes, skin irritation, miscarriages, psychological symptoms, type 2 diabetes, birth defects in their children, and cancers such as Hodgkin’s lymphoma, prostate cancer, and leukemia.
In 1988, Dr. James Clary, an Air Force researcher involved in Operation Ranch Hand, wrote to Senator Tom Daschle: “When we initiated the herbicide program in the 1960s, we were aware of the potential damage due to dioxin contamination in the chemicals. However, because the material was to be used against the enemy, none of us were overly concerned. We never considered that our own personnel could also be contaminated.”
Class Action Lawsuit and Compensation: In 1979, a class-action lawsuit was filed on behalf of 2.4 million veterans exposed to Agent Orange during their Vietnam service. Five years later, an out-of-court settlement was reached, with seven major chemical companies that produced Agent Orange agreeing to pay $180 million to veterans or their families.
Various legal challenges to the settlement persisted for years, including lawsuits from about 300 veterans. Ultimately, the U.S. Supreme Court upheld the settlement in 1988, increasing the compensation to $240 million (including interest).

Agent Orange Act of 1991: President George H.W. Bush signed the Agent Orange Act, designating certain diseases linked to Agent Orange (including non-Hodgkin’s lymphoma, soft tissue sarcoma, and chloracne) as service-related conditions. This law legitimized the U.S. Department of Veterans Affairs (VA) response to affected veterans.
Controversies over Agent Orange and its effects persisted for over four decades. As late as June 2011, debates continued over whether “Blue Water Navy” veterans (those who served on ships during the Vietnam War) should receive Agent Orange-related benefits similar to those who served on land or inland waterways.
Consequences of Agent Orange in Vietnam
Beyond the massive environmental destruction caused by the U.S. chemical spraying program in Vietnam, the country has reported that approximately 400,000 people were killed or disabled due to exposure to chemicals like Agent Orange.
Furthermore, Vietnam claims that half a million children were born with severe birth defects, and about 2 million people suffer from cancer or other illnesses related to Agent Orange.
Lawsuit by Vietnamese Victims: In 2004, a group of Vietnamese citizens filed a class-action lawsuit against over 30 chemical companies, including those that settled with U.S. veterans in 1984. The lawsuit sought billions in damages, arguing that Agent Orange and its toxic effects left a legacy of health issues and that its use violated international law.
However, in March 2005, a federal judge in Brooklyn, New York, dismissed the case. Another U.S. court rejected a final appeal in 2008, sparking outrage among both Vietnamese victims of Operation Ranch Hand and American veterans.
Fred A. Wilcox, author of Scorched Earth: Legacies of Chemical Warfare in Vietnam, told VN Express International: “The U.S. government refuses to compensate Vietnamese victims of chemical warfare because doing so would mean admitting the U.S. committed war crimes in Vietnam. This would open the door to lawsuits that could cost the government billions of dollars.”
Conclusion
Through this Agent Orange article, Thefactsofwar hopes to provide a comprehensive view of the severe consequences this chemical inflicted, from environmental damage and human health impacts to prolonged legal disputes. It serves as a reminder of the responsibility to protect the environment and humanity from chemical weapons in the future. Don’t forget to explore more articles on the Vietnam War in our Vietnam War History category.
Translated by: Minh Tuan
Source: history.com – Agent Orange